The Influence of 1′-Methyl- and 1′-Ethylascorbigen on Metabolism of Arachidonic Acid in Murine Spleen Cells

Add time:07/12/2019    Source:sciencedirect.com

Ascorbigens are indole-containing derivatives of L-ascorbic acid, some or them (e.g., 1′-methylascorbigen) have been shown to inhibit growth or experimental murine tumors. Immunomodulating properties of 1′-methylascorbigen correlated with its antitumor effect. The immunomodulating action of 1′-methyl-ascorbigen is to a marked degree based on its influence on arachidonic acid metabolism in murine spleen cells. A single injection of 50 mg/kg 1′-methylascorbigen leads to pronounced anti immediate increase of the cells′ ability to produce PGE2 and LTB4 (up to 550% and 460%, correspondingly). Till the tenth day after injection the levels of these metabolites of arachidonic acid were double that of the control.

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