1,4-Dihydropyridine activators in the tiamdipine (cas 110646-15-6) series

Add time:08/15/2019    Source:sciencedirect.com

The pharmacologic and radioligand binding properties of 5-nitro analogs of the 1,4-dihydropyridine Ca2+ channel antagonist, tiamdipine (cas 110646-15-6) (2-(2-aminoethylthio)methyl-3-carboethoxy-5-carbomethoxy-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine) and its N-formyl derivative have been measured in rat tail artery, guinea pig ileum and rat heart. The enantiomers of both analogs showed activator and an tagonist properties, the latter being exhibited at lower concentrations.

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