A chemo-enzymatic synthesis of optically active 1,1-diethoxyethyl(aminomethyl)phosphinates: useful chiral building blocks for phosphinyl dipeptide isosteres

Add time:08/15/2019    Source:sciencedirect.com

The kinetic resolution of 1,1-diethoxyethyl(hydroxymethyl)phosphinate possessing chirality at the phosphorus atom was achieved via a lipase-catalyzed acylation. The product was transformed into the corresponding imine, which in turn is a useful starting material for the preparation of phosphinyl dipeptide isosteres.

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