Original paperStudies on antifungal agents 30. Novel substituted 3-(2-furanyl)-3- (1H-imidazol-1-ylmethyl)-2-methyl-5-phenyl(or phenyloxymethy)-isoxazolidinesÉtude sur des agents antifongiques 30. Nouvelles (furanyl-2)-3-(1H-imidazolyl-1 méthyl)-3-méthyl-2 phényl-5 (ou phénoxyméthyl)isoxazolidines

Add time:08/15/2019    Source:sciencedirect.com

The synthesis of a novel class of antifungal agents, the 3-(2-furanyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-phenyl(or phenyloxymethyl)isoxazolidines (10–15) is described. When tested in vitro, derivatives 10–15 exerted a potent antifungal activity against dermatophytes, but were less effective against fungi causing systemic infections. However, analogues 10 and 12 showed minimum inhibitory concentration (MIC) values of 2.0 μg/ml against Aspergillus fumigatus.

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