Efficient chemoselective deprotection of silyl ethers using catalytic 1-chloroethyl chloroformate in methanol

Add time:08/16/2019    Source:sciencedirect.com

Fast and chemoselective desilylation of silyl-protected alcohols was achieved using a catalytic amount of 1-chloroethyl chloroformate in methanol. With a minimal amount of 1-chloroethyl chloroformate as the source for anhydrous HCl, extremely efficient cleavage of silyl ethers of primary and secondary alcohols was accomplished, and chemoselective deprotection of one silyl ether in the presence of another silyl or other acid-labile group was possible through controlling the amount of the chloroformate and reaction time.

We also recommend Trading Suppliers and Manufacturers of 2-[(Triethylsilyl)oxy]ethyl(phenyl) ether (cas 16654-60-7). Pls Click Website Link as below: cas 16654-60-7 suppliers

Prev:An atom-efficient and powerful method for direct esterification of silyl ethers catalyzed by HClO4–SiO2
Next:Rhodium(I) complexes with κP coordinated ω-phosphinofunctionalized alkyl phenyl sulfide, sulfoxide and sulfone ligands and their reactions with sodium bis(trimethylsilyl)amide and Ag[BF4])