Cyclic-tri(N-methyl-meta-benzamide)s: substituent effects on the bowl-shaped conformation in the crystal and solution states

Add time:08/18/2019    Source:sciencedirect.com

Cyclic trimers of 3-(N-alkylamino)benzoic acid (calix[3]amides) with various substituents at the meta position of the phenyl rings were synthesized and the effects of the substituents on the crystal structures and energy profiles in solution were examined. The calixamides existed in a syn conformation in the crystal state, and this was also the major conformation in solution, especially in polar solvents. The energy barrier between syn and anti conformers in the solution was not significantly affected by substituents (12.7–14.0 kcal/mol). The effect of the substituent on the temperature dependence of the syn/anti ratio are discussed.

We also recommend Trading Suppliers and Manufacturers of METHYL 2-BROMO-4-NITROBENZOATE (cas 100959-22-6). Pls Click Website Link as below: cas 100959-22-6 suppliers

Prev:Synthesis of methyl ketones from terminal olefins using PdCl2/CrO3 system mimicking the Wacker process
Next:2-Substituted thiazole-4-carboxamide derivatives as tiazofurin mimics: synthesis and in vitro antitumour activity)