Acute exposure of beta-cells to troglitazone decreases insulin hypersecretion via activating AMPK
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Add time:08/17/2019 Source:sciencedirect.com
BackgroundIt has been recognized that insulin hypersecretion can lead to the development of insulin resistance and type 2 diabetes mellitus. There is substantial evidence demonstrating that thiazolidinediones are able to delay and prevent the progression of pancreatic β-cell dysfunction. However, the mechanism underlying the protective effect of thiazolidinediones on β-cell function remains elusive.
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