Enzymatic desymmetrization of cis-1,3-cyclohexanedicarboxylic acid diesters

Add time:08/18/2019    Source:sciencedirect.com

cis-1,3-Cyclohexanedicarboxylic acid (1,3-CHDA) monoesters were prepared in high overall yield and high enantiomeric purity using a three step process from cis/trans-1,3-CHDA. The asymmetry is induced by an enzymatic hydrolytic desymmetrization of a meso cis-1,3-CHDA diester. A judicious choice of ester substituents and enzyme can provide >80% overall yield of either enantiomer in >94% ee.

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