BACOSIDE A (cas 11028-00-5) and bromelain relieve dichlorvos induced changes in oxidative responses in mice serum
-
Add time:08/19/2019 Source:sciencedirect.com
Reactive oxygen species (ROS) may be involved in the pathogenesis of serum induced by dichlorvos. Therefore, the rationale of present research was to evaluate the ameliorative efficacy of BACOSIDE A (cas 11028-00-5) and bromelain on oxidative stress biomarkers in serum of dichlorvos intoxicated mice. Also the level of serum antioxidants viz. catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and reduced glutathione (GSH) were measured. For experiments, mice were allocated into six groups. First group received saline as a vehicle; second group was administered with dichlorvos (40 mg/kg b.w.); third group was administered with bromelain (70 mg/kg b.w.), fourth group received dose of bacoside A (5 mg/kg b.w.), fifth group was given concomitant exposure of bacoside A and bromelain both and mice of sixth group were exposed to bacoside A, bromelain and dichlorvos for 21 days consecutively. Oxidative stress biomarkers thiobarbituric acid reactive substances (TBARS) and protein carbonyl content (PCC) and antioxidants (CAT, SOD, GPx and GSH) level of serum was determined to elucidate the protective potential of bacoside A and bromelain against dichlorvos intoxication. Significantly increased TBARS and PCC level in second group suggests that dichlorvos enhances the production of free radicals in serum of mice (p < 0.05). Antioxidants treatment significantly decreased the levels of TBARS and PCC (p < 0.05). Dichlorvos administration causes a significant reduction in the level of CAT, SOD, GPx and GSH (p < 0.05) which was restored significantly by co-administration of bromelain and bacoside A in dichlorvos exposed mice (p < 0.05). The bacoside A and bromelain are attributed with antioxidant properties. Finding of research conclude that concomitant exposure of bacoside A and bromelain was much effective in combating oxidative stress induced by dichlorvos.
We also recommend Trading Suppliers and Manufacturers of BACOSIDE A (cas 11028-00-5). Pls Click Website Link as below: cas 11028-00-5 suppliers
Prev:Protective propensity of BACOSIDE A (cas 11028-00-5) and bromelain on renal cholinesterases, γ-Aminobutyric acid and serotonin level of Mus musculus intoxicated with dichlorvos
Next:Elite genotypes of Bacopa monnieri, with high contents of BACOSIDE A (cas 11028-00-5) and Bacopaside I, from southern Western Ghats in India) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Research articleZinc oxide nanoparticles (ZnO NP) mediated regulation of bacosides biosynthesis and transcriptional correlation of HMG-CoA reductase gene in suspension culture of Bacopa monnieri08/25/2019
- Production of BACOSIDE A (cas 11028-00-5), a memory enhancer from hairy root cultures of Bacopa monnieri (L.) Wettst08/24/2019
- Bacoside-A, an anti-amyloid natural substance, inhibits membrane disruption by the amyloidogenic determinant of prion protein through accelerating fibril formation08/23/2019
- Surface modified PLGA nanoparticles for brain targeting of Bacoside-A08/22/2019
- Enhanced bacoside content in polyamine treated in-vitro raised Bacopa monnieri (L.) Wettst08/21/2019
- Elite genotypes of Bacopa monnieri, with high contents of BACOSIDE A (cas 11028-00-5) and Bacopaside I, from southern Western Ghats in India08/20/2019
- Protective propensity of BACOSIDE A (cas 11028-00-5) and bromelain on renal cholinesterases, γ-Aminobutyric acid and serotonin level of Mus musculus intoxicated with dichlorvos08/18/2019
- Attenuation of cytotoxicity induced by tBHP in H9C2 cells by Bacopa monniera and BACOSIDE A (cas 11028-00-5)08/17/2019
- Bacoside-A inhibits inflammatory cytokines and chemokine in experimental autoimmune encephalomyelitis08/16/2019