Characterisation of guanidino-containing antibiotics: Field desorption mass spectrometry of bleomycin B2 and phleomycins D1 and E

Add time:08/17/2019    Source:sciencedirect.com

Because of their complexity bleomycins and their relatives are difficult molecules to structurally characterise. In this paper the first successful field desorption mass spectrometric investigations of these molecules are reported. The recently corrected structure for the glycopeptide skeleton is confirmed and the preparation of a monoacetyl derivative suitable for both mass spectrometric and biological studies is described. The procedures outlined in this paper enable the unambiguous characterisation of closely related members of the bleomycin family and their derivatives, separately or in mixtures.

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