Steffimycin (cas 11033-34-4) B, a DNA binding agent

Add time:08/17/2019    Source:sciencedirect.com

The antibiotic Steffimycin (cas 11033-34-4) B binds to double-stranded DNA as evidenced by difference spectroscopy and an increase of the thermal stability of DNA in the presence of the antibiotic. Salmon sperm DNA · steffimycin B complexes show a drastic decrease in template activity for Escherichia coli DNA polymerase I but not for DNA-directed RNA polymerase. The differences in template properties of poly[d(A-T)] and poly(dG) · poly(dC) · antibiotic complexes, respectively, for DNA polymerase I and RNA polymerase suggest that the antibiotic interacts primarily with adenine or thymine bases or both in double-stranded DNA.

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