13th Congress of the Polish Transplantation Society: Part IIExperimental transplantationEvaluation of the Relationship Between Concentrations of Tacrolimus Metabolites, 13-O-Demethyl (cas 11041-94-4) Tacrolimus and 15-O-Demethyl (cas 11041-94-4) Tacrolimus, and Clinical and Biochemical Parameters in Kidney Transplant Recipients

Add time:08/16/2019    Source:sciencedirect.com

BackgroundTacrolimus (Tac), an essential component of immunosuppressive therapy after solid-organ transplantation, has a narrow therapeutic index and requires therapeutic drug monitoring. Monitoring of Tac predose blood concentrations seems to be not always sufficient to avoid adverse effects. The aim of the study was to evaluate the levels of main Tac metabolites, 13-O-demethyl tacrolimus (13-DMT), 31-O-demethyl tacrolimus (31-DMT), and 15-O-demethyl tacrolimus (15-DMT), in kidney transplant recipients and to link them to clinical and biochemical parameters.

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