Stereoselective approach to uncommon tripeptides incorporating a 2,6-diaminopimelic acid framework: X-ray analysis and conformational studies. Part 4☆

Add time:08/16/2019    Source:sciencedirect.com

Stereoselective synthesis of pseudopeptides 4, 5, 8, 9, 13 and 14, incorporating 2,6-diamino-4-methylen-1,7-heptanedioic acid residue, has been accomplished starting from the l-valine derived chiral synthon 1. The absolute configuration of new stereocentres was assigned on the basis of 1H NMR spectra. The geometry of these unnatural tripeptides was deduced on the basis of 1H NMR parameters and IR spectra. X-ray analysis of the unusual peptide 18 and conformational studies of 5, 9 and 14 are also reported.

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