Pharmacology lettersCGS 15943 (cas 104615-18-1), An adenosine A2 receptor antagonist, reduces cerebral ischemic injury in the mongolian gerbil

Add time:08/17/2019    Source:sciencedirect.com

The adenosine A2 receptor antagonist CGS 15943 (0.1 mg/kg, i.p.) was tested for cerebroprotective activity in a gerbil stroke model. CGS 15943 markedly reduced stroke injury assessed by locomotor activity monitoring and by histopathological measurement of hippocampal CA1 pyramidal cell injury. It is proposed that a previously demonstrated reduction in the ischemia/reperfusion-evoked release of excitotoxic amino acids following CGS 15943 administration could account for its cerebroprotective actions.

We also recommend Trading Suppliers and Manufacturers of CGS 15943 (cas 104615-18-1). Pls Click Website Link as below: cas 104615-18-1 suppliers

Prev:Discriminative effects of CGS 15943 (cas 104615-18-1), a competitive adenosine receptor antagonist, have a dopamine component in monkeys
Next:CGS 15943 (cas 104615-18-1), a nonxanthine adenosine receptor antagonist: Effects on locomotor activity of nontolerant and caffeine-tolerant rats)