Inhibition of inosine monophosphate dehydrogenase (IMPDH) by the antiviral compound, 2-vinylinosine monophosphate

Add time:08/17/2019    Source:sciencedirect.com

A new enzyme-mediated synthesis of 2-vinylinosine, a compound with broad-spectrum RNA antiviral activity, is described. In order to understand the mechanism of action of this compound, we synthesized its monophosphate and investigated the behavior of that compound toward the enzyme, inosine monophosphate dehydrogenase (IMPDH), a key enzyme involved in the biosynthesis of nucleotides. 2-Vinylinosine monophosphate is a potent inhibitor of IMPDH with a Ki of 3.98 μM (kinact=2.94×10−2 s−1). The antiviral activity of 2-vinylinosine may be explained by its cellular conversion to the monophosphate through the sequential action of PNP and HGPRT and subsequent inhibition of IMPDH by the cellularly produced 2-vinylinosine 5′-monophosphate.

We also recommend Trading Suppliers and Manufacturers of 2-Vinyl-9-[beta-d-ribofuranosyl]hypoxanthine (cas 110851-56-4). Pls Click Website Link as below: cas 110851-56-4 suppliers

Prev:Solid phase synthesis of oligoribonucleotides by the phosphoramidite approach using 2′-O-1-(2-chloroethoxy)ethyl protection
Next:Characteristics of dual-type electrochromic device based on poly(3-Tetradecylthiophene (cas 110851-66-6)) and poly(3,4-ethylenedioxythiophene))