Mitochondrial effects of 2,6-DICHLORO-4-NITROANILINE (cas 1331-14-2) and its metabolites☆☆☆★

Add time:08/18/2019    Source:sciencedirect.com

The effects of 2,6-dichloro-4-nitroaniline (DCNA) and its primary mammalian metabolites 3,5-dichloro-4-aminophenol (DCAP) and 2,6-dichloro-p-phenylenediamine (DCPD) were studied on isolated rat liver mitochondria in vitro and ex vivo. DCNA and DCAP inhibited electron transport and uncoupled oxidative phosphorylation in vitro at 1 × 10−5 m, while DCPD produced only slight uncoupling at 2 × 10−4 m. Ex vivo studies at 1000 mg/kg po or 500 mg/kg po revealed a slight increase in respiratory rate and an increased sedimentation coefficient of isolated mitochondria. Urine analysis indicated two pathways of DCNA metabolism in the rat, but interconversion of DCPD to DCAP could not be demonstrated.

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