Metal complexes as radiosensitizers: Cobalt(II), copper(II), rhodium(II) and platinum(II) complexes of 3-(1-imidazoyl)propionic acid and some nitro-substituted derivatives, and the crystal structure and radiosensitizer activity of [CuL2(H2O)]2 · 2H2O, where LH = 3-[1-(4-nitroimidazoyl)]propionic acid

Add time:08/19/2019    Source:sciencedirect.com

The preparations are reported of 3-[1-(4-nitroimidazoyl)]propionic acid, 3-[1-(2-methyl-4-nitroimidazoyl)]propionic acid and 3-[1-(2-nitroimidazoyl)]propionic acid, and also of some cobalt(II), copper(II), rhodium(II) and platinum(II) complexes with these ligands or with 3-[1-imidazoyl]propionic acid. The complexes were characterized by spectroscopic methods, and the compound [CuL2(H2O)]2 · 2H2O, where LH = 3-[1-(4-nitroimidazoyl)]propionic acid, was shown by X-ray diffraction to be dinuclear with each of the organic ligands bonded to two copper(II) ions via the carboxylate groups. Radiosensitization studies on [CuL2(H2O)]2 · 2H2O using hypoxic Chinese hamster V79 cells gave enhancement ratios similar to those for misonidazole, and significantly greater than those for typical, uncomplexed 4-nitroimidazoles.

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