Biodegradable micelles/polymersomes from fumaric/sebacic acids and poly(ethylene glycol)

Add time:08/21/2019    Source:sciencedirect.com

Linear unsaturated oligo-anhydrides containing terminal acylchloride groups have been synthesized by polycondensation of fumaric or sebacic acid with either fumaryl chloride or sebacoyl chloride. Reaction of these oligo-anhydrides with poly(ethylene glycol) produce di- and tri-block copolymers. The oligo-anhydrides and block copolymers have been characterized by gel permeation chromatography (GPC), NMR and FT-IR spectroscopies. The tri-block copolymers composed of two PEG end blocks and an oligo-anhydride center block have been used in encapsulation of calcein (encapsulation efficiency up to 40%). Encapsulation and release profile of calcein (as a model hydrophilic drug) from the di-block copolymers (micelles) and tri-block copolymer vesicles (polymersomes) as well as their in-vitro hydrolytic degradation (pH=7.4°C, 37°C) are reported.

We also recommend Trading Suppliers and Manufacturers of Sebacic acid hydrogen 1-sodium salt (cas 19455-73-3). Pls Click Website Link as below: cas 19455-73-3 suppliers

Prev:Research ArticlePharmaceutics, Drug Delivery and Pharmaceutical TechnologyFluorescence-Based High-Throughput Salt Screening
Next:A low temperature infrared study of the coordinated water in CALCIUM MALONATE (cas 19455-76-6) dihydrate)