Rapid identification of amino acid derivatives from the sequenator

Add time:08/17/2019    Source:sciencedirect.com

A simple procedure is described for converting thiazolinones, from the protein sequenator, to the more stable phenylthiohydantoins without using the conventional HCl conversion procedure. The thiazolinones are applied to a silica gel plate and converted to phenylthiohydantoins by heating at 140° for 5–10 min, in the presence of heptafluorobutyric acid, prior to chromatography. After chromatography, measurements of the yields of the derivatives on the plate can be made with a variable-wavelength thin-layer chromatography scanner. This is shown to be a useful adjunct for identifications.

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