Membrane targeting peptides toward antileishmanial activity: Design, structural determination and mechanism of interaction

Add time:08/18/2019    Source:sciencedirect.com

BackgroundLeishmaniasis threatens poor areas population worldwide, requiring new drugs less prone to resistance development. Antimicrobial peptides with antileishmanial activity are considered among fulfilling alternatives, but not much is known about the mode of action of membrane-targeting peptides, considering promastigote and infected macrophage membranes. In a previous work, structural features of very active known peptides were prospected using molecular dynamics simulations.

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