Synthesis of 3-(Bromomethylene)isobenzofuran-1(3H)-ones through regioselective 5-exo-dig bromocyclization of 2-alkynylbenzoic acids
-
Add time:08/22/2019 Source:sciencedirect.com
A direct synthesis of 3-(bromomethylene)isobenzofuran-1(3H)-ones from 2-alkynylbenzoic acids is developed through a regioselective 5-exo-dig bromocyclization. The reaction proceeds smoothly with a broad substrate scope. The products can be further elaborated via a palladium-catalyze cross-coupling reaction, or can convert to other heterocycles through simple operation. Preliminary mechanistic studies reveal that this transformation undergoes a radical process.
We also recommend Trading Suppliers and Manufacturers of 6-BUTYL-2(3H)-BENZOTHIAZOLONE (cas 135792-92-6). Pls Click Website Link as below: cas 135792-92-6 suppliers
Prev:Synthetic studies toward longeracemine: The intramolecular [4+2] cycloaddition of 3H-pyrroles
Next:Stabilizing mixed fatty acid and phthalate ester monolayer on artificial seawater☆) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Synthetic studies toward longeracemine: The intramolecular [4+2] cycloaddition of 3H-pyrroles08/21/2019
- Neuropharmacology and analgesiaNeuroprotective targets through which 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a sigma receptor ligand, mitigates the effects of methamphetamine in vitro08/20/2019
- 2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity08/19/2019
- 6-Butyl-4-hydroxyquinolin-2-(1H)-one as an enol type coupling component for the synthesis of some new azo disperse dyes08/18/2019
