Radiation crosslinking of carboxymethyl hyaluronic acid

Add time:08/18/2019    Source:sciencedirect.com

Carboxymethyl hyaluronic acid (CMHA) with degree of substitution of 0.5 was synthesized and crosslinked by gamma-irradiation in paste-like state (highly concentrated solution) at doses of 50–100 kGy without the addition of any initiators and crosslinking agents to obtain hydrogels with different properties. Gel fraction of 11–46% which is increasing with dose was obtained. Swelling in water of CMHA hydrogels ranged from 46 to 168 g H2O/g dry gel while swelling in physiological saline solution (0.9% NaCl) ranged from 21 to 31 g saline/g dry gel. FT-IR spectra of the hydrogels revealed decarboxylation and cleavages of glycosidic bond and amide group.

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