Synthesis of monoalkylated calix[4]arenes via direct alkylation

Add time:08/20/2019    Source:sciencedirect.com

A new one-step procedure for the synthesis of monoalkylated calix[4]arenes is presented. Reaction of calix[4]arene 1a or 1b with 1.2 equivalent of a weak base (K2CO3 in MeCN or CsF in DMF) and excess of alkylating agent affords the monoalkylated calix[4]arenes in moderate to good yields.

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