Inhibition of the succinic oxidase system by some structural analogs of succinic and malonic acids

Add time:08/21/2019    Source:sciencedirect.com

SummaryMethionic and 1,2-ethanedisulfonic acids, analogs of malonic and succinic acids, respectively, inhibit the oxidation of succinate. Arsonoacetic and β-phosphonopropionic acids, however, exert no inhibitory action. Other analogs containing rings which fix the spatial orientation of the carboxyl groups (cis- and trans-1,2-cyclopentanedicarboxylic acids, 1,1-cyclobutanedicarboxylic acid, phthalic acid, and o-sulfoben-zoic acid) show inhibitory properties, but they cannot be sufficiently differentiated in their effects to establish the configuration of the enzyme-substrate complex.

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