Efficient synthesis of (R)- and (S)-1-amino-2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID (cas 107873-03-0) via lipase-catalyzed desymmetrization of prochiral precursors

Add time:08/18/2019    Source:sciencedirect.com

The asymmetric syntheses of (+)-(R)-1-amino-2,2-difluorocyclopropane-1-carboxylic acid and its enantiomer have been accomplished. Key reactions in the synthetic design are lipase-catalyzed desymmetrization of a prochiral diol and a prochiral diacetate.

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