Effect of two synthetic α-gliadin peptides on lymphocytes in celiac disease: Identification of a novel class of opioid receptors

Add time:08/20/2019    Source:sciencedirect.com

Two synthetic peptides containing residues 43–47 and 43–49 of α-gliadin were tested for inhibition of leukocyte migration in 47 patients with celiac disease. In nineteen patients, all on a normal diet, leukocyte migration was inhibited by the peptides and naloxone blocked this effect. In twenty-eight patients (24 of whom were on strict gluten-free diet) leukocyte migration was not affected by the peptides. Our results suggest that α-gliadin-(43–49), Tyr-Pro-Gln-Pro-Gln-Pro-Phe, is closely related to the active fragment, or to one of the active fragments of α-gliadin, and that it interacts with receptors that are similar to but not identical with the known opiate receptors.

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