Effects of bolesatine (cas 123896-30-0) on a cell line from the SP2/O thymic lymphosarcoma

Add time:08/21/2019    Source:sciencedirect.com

bolesatine (cas 123896-30-0), a toxic protein isolated from Boletus satanas Lenz inhibits in vitro protein synthesis in a concentration-dependent manner in a cell line from a radiation-induced thymic lymphosarcoma (SP2/O) with a 50% inhibitory concentration (IC50) of 9.5 nM (0.6 μg/ml). In vivo, an i.p. single injection of bolesatine, corresponding to 16 and 110 of 24-h 50% lethal dose, in Balb/c mice having ascitic tumour induced by the i.p. preinjection of SP2/O cells allows a remission of 50% and 30%, respectively. Treated mice survived 120 days after the treatment i.e. 90 days after the death of control animals.

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