Aromatic nucleophilic substitution with 4-HYDROXYPYRIDINE (cas 108-96-3)
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Add time:08/20/2019 Source:sciencedirect.com
The compound 4-hydroxypyridine is reacted with aromatic substrates that have a leaving group (usually halogen) and that is activated by an electron-withdrawing group or a heterocycle. Only N-aryl-4(1H)-pyridones are produced in this efficient aromatic nucleophilic substitution reaction. Some mechanistic aspects of the reaction have also been examined.
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