High-dose trimethoprim-sulfamethoxazole and clindamycin for Staphylococcus aureus endocarditis

Add time:08/20/2019    Source:sciencedirect.com

ABSTRACTObjectiveThe mortality rate for Staphylococcus aureus endocarditis remains as high as 20–30% despite improvements in medical and surgical treatment. This study evaluated the efficiency and tolerance of a combination of intravenous trimethoprim-sulfamethoxazole and clindamycin (T&C) +/- rifampicin and gentamicin, with a rapid switch to oral administration of T&C.

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