A ferriprotoporphyrin IX-chloroquine complex promotes membrane phospholipid peroxidation A possible mechanism for antimalarial action

Add time:08/22/2019    Source:sciencedirect.com

The effect of a ferriprotoporphyrin IX -chloroquine complex on phospholipid membranes was investigated on the basis of iron-induced lipid peroxidation using microsomal phospholipid liposomes. The ferriprotoporphyrin IX -chloroquine complex remarkably promoted peroxidative cleavage of unsaturated phospholipids in liposomes, compared with ferriprotoporphyrin IX alone. Neither the combination of protoporphyrin IX with chloroquine nor the combination of Fe 3+-ADP with chloroquine promoted lipid peroxidation. DL-α-Tocopherol completely inhibited lipid peroxidation induced by the ferriprotoporphyrin IX -chloroquine complex.

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