Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase
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Add time:07/13/2019 Source:sciencedirect.com
The synthesis of ribofuranosyl glycosides of echiguanines A and B, PI 4-kinase inhibitors, was achieved from 2-amino-4-chloropyrrolo[2,3-d]pyrimidine and 2,3-O-isopropylidene-5-O-(t-butyl) dimethylsilyl-α-d-ribofuranosyl chloride. The ribofuranosyl echiguanine A weakly inhibited PI 4-kinase.
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