Column liquid chromatography: Practical aspectInfluence of the kind of the alcoholic modifier on chiral separation on a Chiralpak AD (cas 138361-09-8) column

Add time:08/24/2019    Source:sciencedirect.com

The enantioselective separation of substituted 3-phenoxy-1,2-propanediols (PPDs) and aziridinecarboxylic acid derivatives (ACAs) on Chiralpak AD (cas 138361-09-8), an amylose-based chiral stationary phase, was investigated. All solutes could be separated using hexane-alcohol mobile phases. The retention times for sixteen out of seventeen substituted PPDs and from all the ACAs increased on changing the alcoholic modifier from 2-propanol to ethanol or ethanol-methanol mixtures. The separation factors of sixteen out of seventeen PPDs and nine out of twelve ACAs were improved using ethanol or ethanol-methanol mixtures instead of 2-propanol.

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