Determination of 2-Chloro-4,5-difluorobenzoic acid (cas 110877-64-0) and related impurities by liquid chromatography

Add time:08/19/2019    Source:sciencedirect.com

2-Chloro-4,5-difluorobenzoic acid (cas 110877-64-0) (CDFBA) and related impurities are determined using liquid chromatography (LC). Separations are achieved using a reversed-phase isocratic system with an ion-pair reagent (tetrabutylammonium hydroxide). Unique isomeric impurities observed in commercially produced CDFBA were isolated and identified by NMR and single crystal x-ray diffraction. The method has relative standard deviations of ± 0.55% to ±1.26% for the CDFBA determination and from ±4.3% to ±12% for impurities below 0.3% in CDFBA. Impurities are determinable to at least 0.03% by weight.

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