Original ArticleBiomedicalSynthesis and Anticancer Activity of Novel Ureas and Sulfamides Incorporating 1-Aminotetralins

Add time:08/22/2019    Source:sciencedirect.com

Background and AimsIn the present study, a series of ureas and sulfamides derived from 1-aminotetralins were synthesized. For this purpose, urea and sulfamide analogues were synthesized from the reactions of substituted 1-aminotetralins with N,N-dimethylcarbamoyl chloride and N,N-dimethylsulfamoyl chloride. The anticancer activity of newly synthesized compounds was tested against human U-87MG glioblastoma and PC-3 prostate cancer cell lines. Cytotoxicity was examined using MTT and LDH release assays.

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