Synthesis and enantiomeric excess determination of (6S)-1-(trimethylsilyloxy)-6-(N-methyl-N-benzyloxycarbonylamino)-cyclohexene

Add time:07/14/2019    Source:sciencedirect.com

The title compound was obtained with high regioisomeric and enantiomeric purity starting from the tartrate salt of (1S,2S)-1-hydroxy-2-methylaminocyclohexane. The determination of the enantiomeric excess both of the title compound and of its precursor (2S)-2-(N-methyl-N-benzyloxycarbonylamino)cyclohexanone was determined by NMR experiments with chiral shift reagents.

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