3-Hydroxycoumarins: First direct preparation from coumarins using a Cu2+-ascorbic acid-O2 system, and their potent bioactivities☆

Add time:08/20/2019    Source:sciencedirect.com

First direct 3-hydroxylation of a coumarin ring via a purely chemical system, previously only possible using cytochrome P-450, was successfully conducted by a Cu2+-ascorbic acid-O2 system; the two 3-hydroxycoumarins obtained were novel compounds, 3-hydroxyscopoletin and 3-hydroxyisoscopoletin. 5-Lipoxygenase and α-D-glucosidase inhibitory activities of coumarins greatly increased through 3-hydroxylation. 3-Hydroxyscopoletin and 3-hydroxyumbelliferone had a high inhibitory potency for 5-lipoxygenase and for α-D-glucosidase respectively; they serve as lead compounds for new drugs.

We also recommend Trading Suppliers and Manufacturers of 3-hydroxyscopoletin (cas 127861-47-6). Pls Click Website Link as below: cas 127861-47-6 suppliers

Prev:Metal-free selective synthesis of 2-substituted benzimidazoles catalyzed by Brönsted acidic ionic liquid: Convenient access to one-pot synthesis of N-alkylated 1,2-disubstituted benzimidazoles
Next:Enzyme immunoassay for monitoring aflatoxins in eggs)