Human topoisomerase IB is a target of a thiosemicarbazone copper(II) complex

Add time:08/22/2019    Source:sciencedirect.com

The human topoisomerase IB inhibition and the antiproliferative activity of 3-(4-bromophenyl)-1-pyridin-2-ylprop-2-en-1-one thiosemicarbazone HPyCT4BrPh alone and its copper(II) complex [Cu(PyCT4BrPh)Cl] was investigated. [Cu(PyCT4BrPh)Cl] inhibits both the DNA cleavage and religation step of the enzyme, whilst the ligand alone does not display any effect. In addition we show that coordination to copper(II) improves the cytotoxicity of HPyCT4BrPh against THP-1 leukemia and MCF-7 breast cancer cells. The data indicate that the copper(II) thiosemicarbazone complex may hit human topoisomerase IB and that metal coordination can be useful to improve cytotoxicity of this versatile class of compounds.

We also recommend Trading Suppliers and Manufacturers of copper-thiosemicarbazone complex (cas 127913-88-6). Pls Click Website Link as below: cas 127913-88-6 suppliers

Prev:Research paperX-ray crystal structural and spectral studies of copper(II) and nickel(II) complexes of functionalized bis(thiosemicarbazone) ligands and investigation of their electrochemical behavior
Next:Synthesis and biological evaluation of biotin-conjugated anticancer thiosemicarbazones and their iron(III) and copper(II) complexes☆)