Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide (cas 127943-53-7) as a molecular probe to study the binding of discodermolide (cas 127943-53-7) to tubulin

Add time:08/20/2019    Source:sciencedirect.com

The design, synthesis, and biological evaluation of a simplified fluorescently labeled discodermolide (cas 127943-53-7) analogue possessing a dimethylaminobenzoyl fluorophore has been achieved. Stereoselective Suzuki coupling and Horner–Wadsworth–Emmons reaction comprised the key tactics for its construction. The analogue exhibited qualitatively similar activity to paclitaxel in a tubulin assembly assay, and it can thus be used as a fluorescent molecular probe to explore the local environment of the discodermolide binding site on tubulin. The results of fluorescence measurements on the tubulin-bound analogue are reported.

We also recommend Trading Suppliers and Manufacturers of discodermolide (cas 127943-53-7). Pls Click Website Link as below: cas 127943-53-7 suppliers

Prev:Efficient blue fluorescent electroluminescence based on a tert-butylated 9,9′-bianthracene derivative with a twisted intramolecular charge-transfer excited state
Next:Research PaperThe relationship between Taxol and (+)-discodermolide (cas 127943-53-7): synthetic analogs and modeling studies)