A new and convenient synthesis of 1-aminocyclopropanecar☐ylic acid from cyclopropanone acetal.

Add time:08/20/2019    Source:sciencedirect.com

Cyclopropanone acetal 2a undergoes the one-pot Strecker synthesis under sonication to provide the amino nitrile 8, which after hydrolysis and catalytic hydrogenolysis, gives 1-aminocyclopropanecar☐ylic acid (ACC, 1) in good overall yield.

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