Organocatalytic enantioselective synthesis of N-alkyl/aryl-3-alkyl-pyrrolidine-2,5-dione in brine

Add time:07/13/2019    Source:sciencedirect.com

A highly enantioselective approach has been developed for synthesising chiral succinimide derivatives via asymmetric Michael addition of diketones to maleimide using dihydroquinine as a catalyst in brine. The Michael adducts were obtained in yields up to 98% and with enantiomeric excesses up to 98% ee.

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