A remarkably simple α-oximation of ketones to 1,2-dione monooximes using the chlorotrimethylsilane–Isoamyl nitrite (cas 110-46-3) combination
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Add time:08/24/2019 Source:sciencedirect.com
Ketones undergo α-oximation by NOCl formed in situ from Me3SiCl and isoamyl nitrite, either in solution or under solvent-free conditions, to produce 1,2-dione monooximes in excellent yields. The oximation is regiospecific in appropriate cases.
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