Highly efficient asymmetric reduction of 2-Octanone (cas 111-13-7) in biphasic system by immobilized Acetobacter sp. CCTCC M209061 cells

Add time:08/20/2019    Source:sciencedirect.com

Highly efficient asymmetric reduction of 2-Octanone (cas 111-13-7) to (R)-2-octanol catalyzed by immobilized Acetobacter sp. CCTCC M209061 cells was achieved in a biphasic system. Bioreduction conducted in aqueous single phase buffer was limited due to poor solubility and toxicity towards cells cause by product accumulation. Introduction of [C4MIM]·Ac accelerated the biotransformation process, giving 99% yield, >99% product e.e. and 1.42-fold higher initial reaction rate in conversion of 10 mM 2-octanone as substrate, compared with 99% yield, 97.3% product e.e. and 1.57 μmol min−1 of initial reaction rate in a aqueous single phase buffer system containing 6 mM 2-octanone as the optimal substrate concentration. Moreover, in the [C4MIM]·Ac-containing buffer/n-tetradecane biphasic system, the optimal substrate concentration was enhanced by 83 times (500 mM) in comparison with that in aqueous single phase buffer, resulting in 53.4% yield (267 mM), 99% product e.e. with 8.9 mM g-1 h-1 space time yield.

We also recommend Trading Suppliers and Manufacturers of 2-Octanone (cas 111-13-7). Pls Click Website Link as below: cas 111-13-7 suppliers

Prev:Effects of n-butanol, 2-butanol, and methyl octynoate addition to diesel fuel on combustion and emissions over a wide range of exhaust gas recirculation (EGR) rates
Next:Excess molar enthalpies of binary systems containing 2-Octanone (cas 111-13-7), hexanoic acid, or octanoic acid at T = 298.15 K)