Synthesis and chemical reactivity of the novel 3-chloro-3-(4-chlorocoumarin-3-yl)prop-2-enal

Add time:07/13/2019    Source:sciencedirect.com

Vilsmeier-Haack formylation of 3-acetyl-4-hydroxycoumarin (1) afforded the unexpected 3-chloro-3-(4-chlorocoumarin-3-yl)prop-2-enal (3). Compound 3 reacted with p-toluidine and benzylamine producing Schiff base 4 and enamine 6, respectively. Treatment of compound 3 with hydrazine hydrate produced bis-coumarin 15 which upon treating with hydrazine hydrate afforded bis chromeno[4,3-c]pyrazole derivative 16. Compound 3 reacted with cyanoacetohydrazide under different conditions. Condensation of compound 3 with some heterocyclic amines and 1,2-N,N-binucleophiles was studied. Structures of the new synthesized products were deduced on the basis of their analytical and spectral data.

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