Direct synthesis of methyl 2-diazo-4-aryl-3-butenoates and their application to the enantioselective synthesis of 4-aryl-4-(1-naphthyl)-2-butenoates
-
Add time:08/20/2019 Source:sciencedirect.com
An improved one-flask synthesis of various methyl 2-diazo-4-aryl and 4-heteroaryl-3-butenoates, precursors to donor/acceptor substituted carbenoids, is described. Their Rh2(S-DOSP)4 catalyzed reaction with 1-acetoxy-3,4-dihydronaphthalene, via a combined C–H activation/Cope rearrangement pathway followed by elimination of acetic acid affords a highly enantioselective (98–99% ee) entry to methyl 4-aryl- and 4-heteroaryl-4-(1-naphthyl)-2-butenoates.
We also recommend Trading Suppliers and Manufacturers of vinyl 3-butenoate (cas 19480-15-0). Pls Click Website Link as below: cas 19480-15-0 suppliers
Prev:Synthesis and thermal rearrangement of 5-diazomethyl-1,2,3-triazoles
Next:Regular paperDesigning a catalytic synthesis of 4-methylcoumarin from ortho-iodophenyl 3-butenoate: Ring closure and isomerization control) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- The palladium-catalysed vinylic substitution of vinyl triflates with β-substituted-α,β-unsaturated carbonyl compounds. An application to the synthesis of cardenolides08/28/2019
- Convenient synthesis of 3-fluoro-4,5-diphenylfuran-2(5H)-one from benzoin ethers: Novel and efficient Z–E isomerisation and cyclisation of 2-fluoroalkenoate precursors, substitution of vinylic fluorine☆08/27/2019
- Regioselective coupling of allylic ethers with ethyl 2-trimethylsilyl-3-butenoate08/26/2019
- A general method of synthesis of functionalized Z-vinylic tellurides starting from β-dicarbonyl compounds08/25/2019
- 4.3 - Vinyl Substitutions with Organopalladium Intermediates08/24/2019
- A novel catalytic enantioselective tandem transetherification–intramolecular hetero Diels–Alder reaction of methyl (E)-4-methoxy-2-oxo-3-butenoate with δ,ε-unsaturated alcohols08/23/2019
- Measurement and Correlation of Vapor-Liquid Equilibria for Hexamethyl Disiloxane + Vinyl Acetate System at 101.3 kPa08/22/2019
- Regular paperDesigning a catalytic synthesis of 4-methylcoumarin from ortho-iodophenyl 3-butenoate: Ring closure and isomerization control08/21/2019
-
Health and Chemical more >