Studies on calpain inhibitors. Synthesis of partially reduced isoquinoline-1-thione derivatives and conversion to functionalized 1-Chloroisoquinoline (cas 19493-44-8)s☆

Add time:08/20/2019    Source:sciencedirect.com

Sequential treatment of a (3-substituted-1-thioxo-1,2,3,4-tetrahydroisoquinolin-4-ylidene)acetic acid with thionyl chloride and a nucleophile did not give the expected ester or amide, but a derivative of 2-(3-substituted-1-chloroisoquinolin-4-yl)acetic acid, constituting a simple procedure for the synthesis of functionalized 1-chloroisoquinolines, which can be useful synthetic intermediates. The different reactivity between lactams and thiolactams has been computationally modelled. The activity as calpain inhibitors of both thiolactams and chloroisoquinoline has been measured, finding that some of these compounds are inhibitors in the micromolar range.

We also recommend Trading Suppliers and Manufacturers of 1-Chloroisoquinoline (cas 19493-44-8). Pls Click Website Link as below: cas 19493-44-8 suppliers

Prev:Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a trans-alkene spacer as potent GABA uptake inhibitors
Next:An efficient copper-free Pd(OAc)2/Ruphos-catalyzed Sonogashira coupling of 1-Chloroisoquinoline (cas 19493-44-8)s in the formation of 1-alkynyl-3-substituted isoquinolines)