One-pot synthesis of 2-(quinoxalin-2-yl)benzoate through NBS-mediated sequential reaction of 2-alkynylbenozate and aryl-1,2-diaMine (cas 113638-49-6)
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Add time:08/22/2019 Source:sciencedirect.com
A metal-free route involving a sequential reaction of 2-alknylbenzoate and aryl-1,2-diamine is described for the generation of 2-(quinoxalin-2-yl)benzoate. The sequential reaction combines NBS-mediated diketonization of 2-alknylbenzoate and condensation reaction with aryl-1,2-diamine, and proceeds smoothly under mild reaction conditions and an array of 2-(quinoxalin-2-yl)benzoate is achieved with high efficiency and excellent functional group tolerance. Mechanism studies indicate oxygen transfer reaction is observed and water is incorporated into neighboring ester group.
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