A concise synthesis of 1-(3-hydroxymethyl-4,5-dihydroxyphenyl)-2-tert-butylamino-ethanol (5-hydroxyalbuterol)
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Add time:08/24/2019 Source:sciencedirect.com
An efficient synthesis of 5-hydroxyalbuterol is described starting from 2,3-dihydroxybenzoic acid. The key step utilizes the Stille cross-coupling reaction to install the side-chain functionality.
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