Catalytic enantioselective synthesis of a novel inhibitor of ceramide trafficking, (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)Dodecanamide (cas 112-01-6) (HPA-12)

Add time:08/21/2019    Source:sciencedirect.com

A novel inhibitor of ceramide trafficking, (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide (HPA-12), has been synthesized using a chiral zirconium-catalyzed asymmetric Mannich-type reaction as a key-step.

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