Synthesis, spectroscopy characterization and biological activities of some novel 1-(3-(N,N-dimethylamino)-1-(5-substituted thiophene-2-yl) propylidene semicarbazone Mannich base derivatives

Add time:07/11/2019    Source:sciencedirect.com

The main aim of this work was to synthesise a novel 1-(3-(N,N-dimethylamino)-1-(5-substituted thiophene-2-yl)propylidene semicarbazone Mannich base derivatives and examine the anti-diabetic and anti-inflammatory activities using alloxan-induced diabetic and carrageenan-induced paw oedema methods. These analogues were prepared by performing a condensation reaction between 1-(thiophen 2-yl) ethanone, formaldehyde, N,N-dimethyl amine hydrochloride and semicarbazide. The prepared analogues were characterised by FT-IR, 1H NMR, 13C NMR, mass spectroscopy and elemental analysis. The result reveals that most of the compounds were significantly reduced in the blood glucose level and inflammation of paw volume of experimental animals as compared to the standard drugs.

We also recommend Trading Suppliers and Manufacturers of 3-O-(3-(N',N'-dimethylamino)-n-propyl)glucose (cas 53914-15-1). Pls Click Website Link as below: cas 53914-15-1 suppliers

Prev:Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors
Next:Kinetics of homogeneous and heterogeneous reactions in the reductive aminolysis of glucose with dimethylamine)