Modulation of the voltage-dependent anion channel of mitochondria by ELAIDIC ACID (cas 112-79-8)

Add time:08/22/2019    Source:sciencedirect.com

Dietary trans fatty acids (TFAs) are known to increase the risk of cardiovascular diseases by altering plasma lipid profile and activating various inflammatory signaling pathways. Here we show that elaidic acid (EA), the most abundant TFA in diet, alters the electrophysiological properties of voltage-dependent anion channel (VDAC) of mitochondria. Purified bovine brain VDAC, when incorporated in the planar lipid bilayer (PLB) composed of 1,2-diphytanoyl-sn-glycero-3 phosphatidyl choline (DPhPC) and EA in a 9 to 1 ratio (wt/wt), exhibited complete closing events at different voltages. The closing events were observed at even −10 mV, a voltage at which VDAC usually remains fully open all the time. Additionally, the voltage sensitivity of VDAC was lost in presence of EA; the channel conductance did not decrease with increasing voltages. In identical experimental conditions, membrane containing oleic acid (OA), the cis isomer of EA did not produce any such effect. We propose that EA possibly exerts its adverse effect by modulating VDAC.

We also recommend Trading Suppliers and Manufacturers of ELAIDIC ACID (cas 112-79-8). Pls Click Website Link as below: cas 112-79-8 suppliers

Prev:Research paperAssociation between plasma concentrations of ELAIDIC ACID (cas 112-79-8), a major trans fatty acid, and depression in a nationally representative sample of U.S. adults
Next:Screening method for simultaneous detection of elaidic and vaccenic trans fatty acid isomers by capillary zone electrophoresis)